In this powerful return episode, Michele Hughes welcomes back Ryan Smith, founder and Chief Scientific Officer of TruDiagnostic. Formerly the CEO of Tailor Made Compounding, Ryan transitioned his focus from peptides to epigenetic science, becoming a leading force in the field of biological aging. This episode is a deep-dive tutorial on biological age testing, DNA methylation, and how epigenetics can give us control over the aging process.

Ryan explains the difference between chronological and biological age, the power of DNA methylation data, and the cutting-edge technology behind TruDiagnostic’s comprehensive testing. Listeners will also learn about telomeres, organ-specific age reports, and the groundbreaking “Rejuvenation Olympics.” Michele shares her own test results and explores how these tools offer insight into one’s aging trajectory and risk factors for chronic disease.

Whether you’re new to biohacking or a longevity enthusiast, this episode offers a front-row seat to the future of preventative health.

🧬 Topics Covered:

• Ryan’s journey from medical school dropout to peptide pioneer and scientific director
• What peptides and peptide bioregulators really are
• Understanding epigenetic clocks and why biological age matters more than chronological
• The science of DNA methylation and how it measures gene expression
• Differences between traditional DNA tests and epigenetic testing
• Why telomere testing is outdated and less predictive
• What TruDiagnostic’s tests reveal—from organ system age to personalized healthspan insights
• Data-driven interventions for slowing and reversing aging
• How TruDiagnostic’s “TrueHealth” report may soon replace traditional blood tests
• Clinical trials, FDA approval pathways, and the future of aging diagnostics

🔗 Learn More & Order a Test:

Visit www.trudiagnostic.com and use code AGELESS20 for 20% off.
Connect with Ryan Smith on LinkedIn for more insights and research updates.

Medical Disclaimer – Ageless and Timeless PodcastAgeless and Timeless (the “Show”), along with its host and guests, shares insights and discussions on health, wellness, and longevity for informational and educational purposes only. The Show does not provide medical advice, diagnoses, treatments, cures, or preventative recommendations for any disease or health condition. The content shared should not be used as a substitute for professional medical advice, diagnosis, or treatment.While we strive to feature reputable sources and knowledgeable guests, neither Ageless and Timeless nor its host or affiliates assume responsibility for errors, omissions, or misinterpretations in the information provided. Listeners are encouraged to use their own discretion and consult with a licensed medical professional before making any health-related decisions. By listening to this podcast, you acknowledge that any actions you take based on the information presented are at your own risk, and Ageless and Timeless, its host, guests, and affiliates are not liable for any direct, indirect, incidental, or consequential damages resulting from the use of this content.