The aim of the course will be to instruct students in the latest developments of this field, especially with regards to its connection with human disease and the development of novel therapeutic approaches, and key topics of animal experimentation. The course will be taught by a series of high level international experts that have been at the forefront of mouse research since its beginning. Topics: basic principles of mouse genetics - Mutagenesis approaches (CRISPR/Cas9) - Phenotyping, Informatics and Database - The use of mouse disease models as a diagnostic and therapeutic tool - Mouse Sperm Cryopreservation and Recovery - In-Vitro Fertilization and embryo manipulation.