In this Journal Club episode, our Faculty, Dr. Joseph Mikhael and Dr. Krina Patel, discuss what clinicians need to know about optimizing treatment strategies for their patients with multiple myeloma. They explore approaches to bridging therapy to improve efficacy and reduce toxicity, evidence-based principles for sequencing B-cell maturation antigen (BCMA)-targeted agents, and how to navigate the challenge of prior BCMA exposure to improve patient outcomes.Visit https://suitehome.atpointofcare.com/library/2676.13/page/0?subdomain=myeloma to view the activity and CME/CE information, download the transcript, and complete the posttest and evaluation to earn CME/CE credit.