Methotrexate is a well-established drug used in oncology, but could it also play a role in managing osteoarthritis? In this episode of Joint Action, Professor David Hunter is joined by Dr Anna Døssing and Professor Robin Christensen to explore the potential of methotrexate as a treatment for osteoarthritis pain.

They discuss:

• What methotrexate is and how it works
• Insights from a recent meta-analysis on its effectiveness and safety
• Why individual studies show mixed results
• Whether it might help people with hand or knee OA - especially those with signs of inflammation
• How dosing and side effects factor into clinical decision-making

Tune in for an honest, data-driven conversation about repurposing an old drug for a new purpose - and what it could mean for people living with osteoarthritis.

RESOURCES

• Editorial: Methotrexate for osteoarthritis—Ready for clinical use and in whom?: https://www.oarsijournal.com/article/S1063-4584(25)00973-2/abstract?

CONNECT WITH US

• Twitter: @ProfDavidHunter @jointactionorg
• Instagram: @osteoarthritisresearchgroup
• Email: osteoarthritis.research@sydney.edu.au
• Website: https://www.jointaction.info/podcast

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