This episode is a conversation with Professor Anne Vincent-Salomon from Institut Curie, Paris and Dr. Maxim De Schepper from University Hospitals Leuven, Belgium. The topic is the European Lobular Breast Cancer Consortium study aiming to harmonize the pathological diagnosis of ILC by comparing 5 commonly used E-cadherin antibody clones (NCH-38, EP700Y, Clone 36, NCL-L-E-cad [Clone 36B5], and ECH-6). Based on the study findings, the guests describe the indication for E-cadherin staining, choice of antibodies, and IHC interpretation to standardize ILC diagnosis in current pathology practice