If powerful AI ends disease and poverty, what comes next for humanity?

In this Thinking on Paper pocket-edition, Jeremy and Mark dissect Anthropic CEO Dario Amodei’s essay Machines of Loving Grace. Amodei sketches a near-term world—five to ten years—where reliable cures for infectious disease, most cancers, Alzheimer’s and even genetic disorders, are a reality.

The conversation pushes that optimism up against tougher questions: who owns the data-center “country of geniuses,” how rich and poor nations close the access gap, and where humans find purpose once work and scarcity recede.

Highlights:

• Nobel-class models tackling biology, neuroscience, economics and governance in parallel, compressing a century of progress into a decade

• Mental-health cures and “biological freedom” on the table—alongside scepticism about complexity limits machines of loving grace

• GDP gaps, universal basic income and why the “human in the loop” remains the toughest bottleneck

• Meaning, creativity and empathy as the last levers humans may still control

Please enjoy the show. And share with a curious friend.

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Read the essay: https://www.darioamodei.com/essay/machines-of-loving-grace#fn:1

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Chapters

(00:00) Machines Of Loving Grace

(02:46) Dario Amodei's Definition Of Powerful AI

(05:11) Speed Of The Outside World

(07:24) Complexity

(11:27) List Of Diseases AI Will Cure

(13:46) Neuroscience And Mind

(15:45) AI For Everyone?

(21:33) Peace And Government

(25:03) Work And Meaning

(31:56) What's Meaningful?

(34:27) Taking Stock

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